The 6 Best 12 hour Cough medicines (2023 reviews)

12 hour cough medicines
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Are you looking for collection of best 12 hour cough medicines ? This page is just for you.

Our review process:

Our Top Picks:

Best Overall:
Buy: Mucinex 12 hour Cough Medicine
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Best For Nighttime:
Buy: Mucinex extended release
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Best For child:
Buy: Amazon Basic Care 12 hour Cough Medicine
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Best For stuffy Nose:
Buy: Guardian 12 hour Cough Medicine
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Best For irritating Cough:
Buy: Robitussin 12 hour Cough Medicine
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Best For Your bucks:
Buy: OHM 12 hour Cough Medicine
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Best Overall: Mucinex 12 hour Cough Medicine

Mucinex 12 hour Cough Medicine
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The mucinex 12 hour cough medicine is the best feature-rich medicine on the market today. This stuff breaks down mucus and helps significantly to alleviate that cough. It really does help with congestion and mucus. These are the size of horse pills, (yup they are huge) and they certainly help take care of the congestion and drain. It relieves chest congestion caused by excess mucus by making your cough more productive.

These tablets are easy to swallow & work fairly quickly for up to 12 hours. It has no effect on your nerves, as decongestants do, and it works perfectly as long as you drink adequate water throughout the day. These last 12 hours with slow release and lasts much longer.

Why We Like This:
  • Works great for congestion and chronic pain-only discontinued auto ship due
  • The best for day time relief
  • Aside from mucous build-up also helps with pain and vertigo

Best For Nighttime: Mucinex extended release

Mucinex extended release
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Not everyone likes to purchase medicine for their daily usage, but the mucinex extended release would be an anomoly. It is great for relief of chest congestion associated with allergies. It has a pain medicine and fever reducer which is a nice addition to the formula. It also can help with dry mouth. The smaller size pills are way esier to swallow than the larger delayed-release horse pills. It has 600 mg, while the maximum strength has 1200 mg.

If you are willing to take them with the suggest 8oz of water and drink water throughout the day, they really do help keep congestion broken up so sinuses can drain properly and lungs can cough out mucous easily, preventing infections from buildup that can occur otherwise. It is great for people who suffer from chronic sinusitis and nasal infections.

Why We Like This:
  • Easier to swallow & easier on the stomach
  • Great product to help loosen congestion
  • A must-have for sc allergy season
  • Easy to transport with individual seal

Best For child: Amazon Basic Care 12 hour Cough Medicine

Amazon Basic Care 12 hour Cough Medicine
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Best part: amazon basic care 12 hour cough medicine costs comparatively low and it is available to ship in 24 hours. It's good for those who don't like to take an "all in one" type of medicine with multiple ingredients that you do not need. Amazon Basic Care maximum strength mucus relief dm tablets contain dextromethorphan hbr and guaifenesin. It contains guaifenesin to help loosen phlegm so you can cough up that bothersome mucus. The active ingredient is Dextromethorphan (60mg) and Guaifenesin (1200mg) and works identically to the Mucinex DM version. It works well and definitely slows/stops coughing. They really control your cough well and are WAY cheaper than the name brand or store brand.

Why We Like This:
  • Priceless otc medicine for congestion and cough
  • Tastes fine and easy to swallow
  • Really clears your sinuses out, helps you cough up junk and stay clear

Best For stuffy Nose: Guardian 12 hour Cough Medicine

Guardian 12 hour Cough Medicine
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The guardian 12 hour cough medicine should be able to handle its purpose and duties with ease. This is a maintenance medicine for an elderly parent with dexterity issues. It's satisfactory and a much more economical alternative to name brands. It works well to reduce mucus, a little hard to swallow though. They come individually rapped so it is easy to see if someone popped out several pills.

The size of these tablets are so much smaller than the regular tablets. They are easy to swallow and do a great job. It is all extended release but does start acting right away. It is best for a plug up head and sinyses.

Why We Like This:
  • Easier to remember to take twice a day in this longer acting pill
  • Helps head and chest congestion, works just like mucinex
  • Good for cough, cold, chest congestion
  • Dye free and last through the night

Best For irritating Cough: Robitussin 12 hour Cough Medicine

Robitussin 12 hour Cough Medicine
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We know from years of feedback from readers, customers and amazon sellers, what most people want in a convenient and appropriate medicine. The robitussin 12 hour cough medicine is exactly that - it's a simple medicine that hits all the right notes. It’s never just a cough, so get fast and effective relief from your cough symptoms for 12 hours. Powerful cough tablets relieve chest congestion and frequent coughs to send your cold symptoms packing. It is formulated with an effective expectorant that thins mucus in the lungs to help clear airways so coughs are more productive. It is great for early sore throat symptoms.

These are slow release tablets and they work to loosen phlegm in your chest which will cause you to cough at first, but the coughing will be more effective and end up reducing coughing overall. It comes with those things in mind, if you want something to work for a cough, this stuff does help.

Why We Like This:
  • Stops the dry hacking cough, and allows you to sleep better
  • Solid choice and one to keep on hand
  • One of the new comers and featured product

Best For Your bucks: OHM 12 hour Cough Medicine

OHM 12 hour Cough Medicine
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We would, of course, be remiss if we didn't mention ohm 12 hour cough medicine for daily purpose. It helps loosen mucus and lessen the severity of coughing. Do not crush, chew or break the tablet with a full glass of water, this product can be administered without regard for the timing of meals, adults and children 12 years of age and over, 1 tablet every 12 hours. It's great for congestion. This is 1 tablet for 6 hours, or 2 tablets for 12 hours. It works great for colds (flu) and seasonal allergies. It's great to clear up froggy throats.

Why We Like This:
  • Good investment for long term
  • One of the new comers and featured product