The 12 Best Antihistamine medications (2023 reviews)

The rite aid antihistamine allergy medicine's superior materials makes sure that it ages well with use. It's like Benadryl and it can make you drowsy. If you use the famous Ben brand, for allergy relief, or as a sleep aid, this is just as effective at a much better value. It includes 365 coated minitabs plus it is designed in an easy-to-swallow small tablet.

The only mention of the ingredient is Diphenhydramine, there is no other ingredients such as Talc, talcum powder or magnesium silicate which is the pharmaceutical name for talcum powder. They work just as well and they are a great value for the money for the quantity that you receive. It is great value for this many pills.

Why We Like This:

Good stuffworks well for eye and nose allergies, makes you a bit sleepy
Fast acting allergy and itch relief
Easy to swallow with no weird smells that sometimes come with generic medication

Best For Seasonal Allergy: Welmate Antihistamine Medication

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The welmate antihistamine medication gives the top-tier medication a run for their money by offering flagship specs at a much more affordable price. Stocking up on levocetirizine in your cabinet is the perfect solution for anyone needing immediate allergy relief. It contains levocetirizine dihydrochloride 5 mg, an antihistamine which compares to the active ingredient in xyzal allergy 24hr. It provides a full 24 hours of coverage to ensure day and night support. It is clinically proven to provide long-lasting relief from indoor and outdoor allergies. It provides you all-day support from sneezing, runny nose, itchy/watery eyes, itchy nose & throat caused by pollen, dander, dust, cats and dogs, trees and flowers. It is bottled as a 3 month supply which is helpful, too.

Why We Like This:

Relieves eye pain due to season alergies
Works on indoor and outdoor allergens
New and hot release

Best For Congestion: Allegra Antihistamine Medication

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We would, of course, be remiss if we didn't mention allegra antihistamine medication for daily purpose. Allegra Adult allergy medicine starts working in one hour to give you fast, non-drowsy,. It works well but also causes drowsiness. Allegra tablets start working in one hour to give you round-the-clock relief from sneezing, runny nose, itchy and watery eyes, and itchy nose or throat. It is indicated for the temporary relief of symptoms due to upper respiratory allergies or hay fever, which can be caused by an allergic response to indoor or outdoor allergens.

Allegra allergy medicine won’t cause drowsiness, so you don’t have to worry about feeling tired after you take it. It gives you an option for auto ship.

Why We Like This:

Great over night travel game changers
Helps control allergy symptoms year round
24 hour relief is awesome and homely

Best For NIGHTTIME: Xyzal Hour Relief

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We would, of course, be remiss if we didn't mention xyzal hour relief for daily usage. This is a great allergy medicine. It provides continuous allergy relief that is just as effective at hour 24 as it is at hour. The Xyzal is taken at night before going to bed so you wake feeling refreshed and symptom-free in the morning when pollen is at its worst. It works effectively for at least 24 hours. If you have a mild to moderate dog allergy, this works great. They will make you sleepy like Benadryl.

Why We Like This:

Works soo fast with no grogginess
Sleepy side effects, works as well as benadryl
Good investment for long term

Best For Non drowsy: Claritin Antihistamine Medication

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Claritin offers a variety of medication for personal choice and yet maintaining quality in all the variants. This product works very well for hay fever treatment. It is great for spring time. The active ingredient in Claritin non-drowsy is loratadine. It keeps the nasal clear and cough down. It works and only one pill a day makes it so convenient. It does relief the allergy symptoms by quite some. It is easy to swallow and works the best of all the allergy remedies.

Why We Like This:

More itching, tickling, runny nose, sneezing
Worth the money to have general allergy relief without being drowsy
New and hot release

Best For run: Gencare Antihistamine Medication

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The gencare antihistamine medication is satisfactory and appropriate and fits well with your regular usage. The GenCare Cetirizine HCL 24 hour non-drowsy allergy pills are a purchase alternative due to pricing of Zertek. It has titanium dioxide in the ingredients and it's the last ingredient which means it doesn't have much. It works well without extra ingredients. The tabs are indented in the middle if you prefer a half dose.

This generic brand works just as well as the name brand and is easy to swallow and gets to work very quickly. It's non-drowsy. This is a money saver for anyone that uses allergy meds on a regular basis. It is good for indoor pets.

Why We Like This:

Works really well and good value
Excellent allergy relief and value for money
Sleepiness, no upset stomach and works quickly

Best For Allergy sufferer: Basic Care Antihistamine Medication

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The basic care antihistamine medication is capable of outshining several other medication featured in this list in overall features in its price range. This histamine blocker temporarily relieves symptoms due to hay fever or other upper respiratory allergies. It comes with non-drowsy allergy relief from amazon basic care 24 hour allergy relief loratadine tablets 10 mg, so you can stop sniffling and struggling with symptoms of indoor and outdoor allergies. They come in blister packaging that can be separated to bring along just one pill while leaving it wrapped.

The Basic Care brand is great-it comes in large quantities and is priced nicely for family allergy sufferers. These work just as well as Claritin, just as effective, and keep symptoms at bay for just as long. The top is child proof but not hard to open and close.

Why We Like This:

Recommend for ingredients and great for hiking/camping
Economical (generic - loratadine) to claritin
One of the new comers and featured product

Best For daytime: Claritin oral Allergy Brand

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The claritin oral allergy brand is suitable and reliable and fits well with your daily purpose. Claritin is an otc medication that can be taken daily to assist with common allergies. This bundle pack includes both claritin tablets and claritin liqui-gels, so you can choose the format that best suits your needs. It's the tiniest of all the tablets, a white, spherical pill that's really easy to swallow. The non-drowsy formula keeps you from feeling groggy, but it actually can help you sleep at night by fighting the many allergy symptoms that can keep you awake.

This pack comes with some clear liqui gels as well. Claritin won't help you sleep, but it will take care of those annoying allergies. This stuff works and is super effective. The Claritin tablets are easy to swallow and provide you with 24 hours of allergy relief from symptoms such as sneezing, runny nose, itchy and watery eyes, and itchy throat.

Why We Like This:

Claritin tablets and capsules provide powerful,
Drowsy allergy relief in a convenient package
Good bundle of tablet and liquid gel forms

Best For Allergic reaction: Healthcareaisle Antihistamine Medication

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Healthcareaisle offers a variety of medication for personal choice and yet maintaining quality in all the variants. Fexofenadine tablets provide 24 hours of allergy relief. This is a second generation of antihistamines. It has the same active ingredient as allegra allergy 24 hour tablets. It is a good substitute for the prescribed fexofenadine. This magic pill takes care of it all. It is a non-drowsy allergy medicine that provides effective relief from indoor and outdoor allergies.

Why We Like This:

Non drowsy and only take one dose per day
More sneezing, sniffling, rashes, hives, difficulty breathing, runny noses, dry/watery/itchy eyes
New and hot release

Best For Spring Allergy: Welmate Name Brand

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The welmate name brand's superior materials makes sure that it ages well with use. Fexofenadine works very well for myself and family with no drowsiness. This brand is very affordable and it works great. They seem equally as effective and the smooth, oblong tablet is easy to swallow. It works better with decongestant pill also.

This beauty reduces drainage, coughing and head miseries. The caplets are very easy to swallow. It is good for mild allergies only.

Why We Like This:

Five stars on tough allergies for people who need everyday relief
Priced fairly and easy to swallow
Very effective allergy medicine without drowsiness

Best With Nasal decongestant: Xyzal Antihistamine Medication

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Not everyone likes to purchase medication for their regular usage, but the xyzal antihistamine medication would be an anomoly. It is easy to swallow pills, they really work. It works better than most allergies medication. The pills themselves are very tiny and easy to swallow. It's a bit of a stretch that it claims to give you 24 hours of relief.

Xyzal is taken at night before going to bed so you wake feeling refreshed and symptom-free in the morning when pollen is at its worst. It works as well as Benedryl without the day sleepiness. It is effective for 24 hours and that it is recommended to be taken at night.

Why We Like This:

Wet eyes, no drippy nose, no itchiness or sneezing, it's amazing
Good value & convenient to buy on line
Doesn't make you feel drowsy or hype you up
Easy to take, don't leave a taste in your mouth

Best For Sinus condition: Rite Aid Antihistamine Medication

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The rite aid antihistamine medication should be able to handle its purpose and duties with ease. This allergy pill relieves mild (not severe) allergies. It has an antihistamine for allergies (chlorpheniramine maleate) and a decongestant. It has an allergy and it stops congestion. It is good for congestion at night. These two ingredients are the perfect combination for sinus headaches associated with colds. This allergy medication works better than benadryl and doesn't have the side effect of making you sleepy. It is easy to take and only causes some drowsiness if you are tired. This is a great product for sinus drainage and congestion.

Why We Like This: