The 11 Best Methyl Support Supplements (2023 reviews)

There are several advantages of having a methyl support supplement. Let’s take you step by step, type by type, and find the best methyl support supplement for you.

Our review process: Show/Hide

Our Top Picks:

Best Overall: Buy: Moxyvites Methyl Support Supplement READ REVIEW

Best For Stress: Buy: omnibiotics Methyl Support Supplement READ REVIEW

Best For diabetes: Buy: Igennus healthcare Nutrition Methyl Support Supplement READ REVIEW

Best For acne: Buy: 1 body Methyl Support Supplement READ REVIEW

Best For men: Buy: Quicksilver scientific Methyl Support Supplement READ REVIEW

Best For pregnant: Buy: Pure Encapsulations Methyl Support Supplement READ REVIEW

Best With Magnesium: Buy: Solaray Methyl Support Supplement READ REVIEW

Best For fish: Buy: Klaire Labs Methyl Support Supplement READ REVIEW

Best For anemia: Buy: Methylpro Methyl Support Supplement READ REVIEW

Best For Brain Health: Buy: Davinci Methyl Support Supplement READ REVIEW

Best For anxiety: Buy: Xymogen Methyl Support Supplement READ REVIEW

Best Overall: Moxyvites Methyl Support Supplement

Buy on Amazon

We know from years of feedback from readers, customers and amazon sellers, what most people want in a supplement. The moxyvites methyl support supplement is exactly that - it's a simple supplement that hits all the right notes. This B-Complex is formulated with the finest ingredients to bring you the best quality product. It helps support energy, healthy skin, metabolism and is vegan. All sugars dissipate during the dehydration process of the ingredients, so there are no sugars. It is good for brain and nerve health. The supplement facts on the bottle are easily listed with all the ingredients.

The body will use what it needs and any surplus is excreted in the urine. They all work in unison this way, plus it's easier than taking multiple pills. There is an image of the entire label with all the information and it’s contents.

• Great source of natural vitamin b
• More energy and quick nutrition for the cells
• Good quality product, eat after breakfast

Best For Stress: omnibiotics Methyl Support Supplement

Buy on Amazon

The omnibiotics methyl support supplement gives the top-tier supplement a run for their money by offering flagship specs at a much more affordable price. This is the best form of B vitamins and good for methylation. It helps turn carbohydrates into energy, break down fats and proteins, and support muscles in the gi tract. It is designed to minimize the risks involved in any pharmaceutical production that cannot be eliminated through testing the final product.

These B-complex are full spectrum great for the nervous system. This capsule goes down easily with a big teaspoon of apple sauce. It is perfect for men too, lol. It is perfect for those with the mthfr gene which prevents normal absorption of b vitamins.

• Good dosages of all the b-vitamins & includes choline
• Very high quality vitamin that is easy to swallow
• Appears to help with focus, thinking, clarity and calmness, and overall motivation

Best For diabetes: Igennus healthcare Nutrition Methyl Support Supplement

Buy on Amazon

Next on the list, we've got yet another supplement that manages to win our hearts. It's the igennus healthcare nutrition methyl support supplement and it's widely considered as one of the best convenient supplement you can buy. These are designed to introduce the best qualities a substantive B-complex vitamin has to offer. With this product "MENTHOLATED" is key in this vitamin being quickly absorbed by the body, hence it meets that key element. It smells like cod liver oil when you open the bottle. It has two identical alleles of the mthfr gene or genes. These have more endurance now, energy more even thru the day.

There are other vitamins in them such as B1 B2 Bitamin c & biotin. They are really absorbable for those who are b12 difficient. It is easy to swallow with a juice.

• A good balance of absorbable vitamins
• Has no flavor and easy to swallow
• Lot of satisfied buyers

Best For acne: 1 body Methyl Support Supplement

Buy on Amazon

If you often find yourself confused about convenient and suitable supplement, 1 body methyl support supplement should be your first option for buying. This vitamin delivers most if not all B's in one dose. It does not have folic acid, only l-methyltetrahydrofolate. It also turns your urine very yellow. This formula doesn't have the extra fillers, like magnesium stearate. It is good for mental and physical endurance. The capsule is small and easy to swallow.

• Pills are easy to swallow and no after taste
• Very good to add to your low carb diet
• Take a zinc supplement to help curb cystic acne

Best For men: Quicksilver scientific Methyl Support Supplement

Buy on Amazon

Best part: quicksilver scientific methyl support supplement costs comparatively low and it is available to ship in 24 hours. These pump action bottles are absolutely useless at delivering a consistent dosage once you get to the last 1/5 of the bottle. It’s easy to use, just 2 pumps a day is what it says on the bottle unless your doctor says otherwise. It includes trimethylglycine, which serves a vital role in methylation, and milk thistle to support the liver. It can be necessary for energy metabolism, detoxification, immunity, balanced mood, cognitive function and gut health. It makes your pee super yellow so that means it's working right.

This product has a clear consistency that can only be achieved with liposomes that are small enough to pass between cells. The package calls for 2 pumps a dose which is A LOT of B vitamins.

• Each bottle contains 50 servings of liquid vitamins for women and men
• Take on an empty stomach, at least 10 minutes before meals
• Good investment for long term

Best For pregnant: Pure Encapsulations Methyl Support Supplement

Buy on Amazon

If you often find yourself scrambling for appropriate and satisfactory supplement, pure encapsulations methyl support supplement should be your first option for buying. The Pure Encapsulations MethylAssist does not contain Niacin/B. It supports essential methylation reactions to support cardiovascular and neural health with metafolin l-5-methyltetrahydrofolate (l-5-mthf), the naturally occurring, universally metabolized form of folate, and activated b vitamins. It maintains healthy nervous system function and comfort including healthy nerve conduction velocity.

All Pure Encapsulations ingredients, including those derived from corn, are GMO free from wheat, eggs, tree nuts & peanuts, gluten, artificial colors, flavors & sweeteners, coatings and shellacs, GMOs, and unnecessary binders, fillers & preservatives. These are free from unnecessary additives and many common allergens.

• Very small, powder-filled capsules that are easy to swallow
• All ingredients are tested for purity and potency by independent certified laboratories
• Delivers what they promise

Best With Magnesium: Solaray Methyl Support Supplement

Buy on Amazon

Solaray has been making great supplement for years, thanks to a combination of clever design and appropriate materials. A group of important water-soluble vitamins with similar functions in the body, B-Complex Vitamins help support healthy hair and skin, nerve impulse transmission, immune system function, and red blood cell formation. It also uses the high quality Quatrefolic bioavailable version of folic acid (you can look it up) which is much healthier and much more easily absorbed than regular folic acid. The methylated form of folate and Vitamin B-12 may be more bioavailable forms for those who struggle to absorb these nutrients.

Nutraceutical’s lab verification procedure includes testing for heavy metals, microbes, bacteria, herbicides, pesticides, major allergens, and purity, identity, and potency. This product is not intended to diagnose, treat, cure or prevent any disease.

• Natural and easy to absorb and use all nutrients
• Work together to aid in the metabolism of carbohydrates, fats and proteins
• Natural supplement easily absorbed in system

Best For fish: Klaire Labs Methyl Support Supplement

Buy on Amazon

We would, of course, be remiss if we didn't mention klaire labs methyl support supplement for regular usage. This product is an easy-to swallow & effective B vitamin, that provides way more than the minimum required % values. Vitamins B2, B6, B12, and folate are provided in active, coenzyme forms for maximum bioavailability and function. These ingredients work together to synergistically support methylation processes and help maintain normal homocysteine metabolism.

This product is not intended to diagnose, treat, cure or prevent any disease.

• Activated b vitamins plus tmgmethyl balance
• Contains no artificial colors, flavors, or preservatives
• Hypoallergenic product free of the following common allergens

Best For anemia: Methylpro Methyl Support Supplement

Buy on Amazon

The methylpro methyl support supplement's high-end materials makes sure that it ages well with use. Doctors who are most familiar with L-Methylfolate, have developed this comprehensive Methyl B Complex exclusively designed to help fill nutritional gaps with one convenient capsule. It is the leading nutraceutical line featuring l-methylfolate, the most active, advanced form of folate. It includes niacin, vitamin b6, choline, vitamin c, and more. It absorbs very well.

It is free of gluten, dairy, eggs, and nuts. The Amber glass filters out blue and uv light, lessening the chance the product will become less potent. It is important for the production of neurotransmitters involved in concentration, sleep, hormones, mood stability and energy.

• Fills the gap between genetics and normalcy
• Lifeline to happiness and depression recovery
• New and hot release

Best For Brain Health: Davinci Methyl Support Supplement

Buy on Amazon

Davinci offers a variety of supplement for personal choice and yet maintaining quality in all the variants. Homocysteine supplements may promote improved focus and attention span so you may remember where you put your car keys or cellphone. This methylation and methylfolate supplement helps keep you energized. It is formulated with folate easy for body to use and store. These vitamins are critical for healthy red blood cells.

The ingredients in this mood supplement encourage an optimistic attitude. It is critical for utilization of b6 vitamins and folate. This keeps you in a happy, upbeat mood.

• Methyl b12 supplement formulated with folate easy for body to use and store
• Unwanted binders, fillers or artificial ingredients
• Vitamins b2, b6, b12, and folate all feed your brain cells
• Methyl benefits contains heart and liver vitamins

Best For anxiety: Xymogen Methyl Support Supplement

Buy on Amazon

Compared with other supplement in this category, the xymogen methyl support supplement has a convenient design. XYMOGEN’s Methyl Protect is an extremely well thought out Vitamin-B Complex supplement. The B complex nutrients in this formula are provided in activated forms (methylated b12, methylated folate, pyridoxal 5 phosphate, riboflavin 5 phosphate) to support enhanced methylation and overall cardiovascular health. They’re pharmaceutical grade and digest easily without any aftertaste or intestinal issues.

The Methyl Protect is highly absorbable and helps to support healthy methylation. They do not have a bad taste, or aftertaste. The capsules are kind of big but not hard to swallow. The serving size does not require you to take multiple, or muliple servings a day like some B vitamins. It can lead to risk for dementia, stroke & heart disease.

• Easy to swallow and no taste
• Very substantial quantities of b2, b6, b12, and folate, including folate as quatrefolic
• Absorbs at a better rate than most other vitamins out there
• B-complex vitamins with a very high %daily value per capsule