The 10 Best Over The counter Antihistamine Pills (2023 reviews)

over the counter antihistamine pills
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We consider a over the counter antihistamine pill to be a worthy investment in the long run. We are here to help you choose the right one for your needs from all the best available products in market today.

Our review process:

Our Top Picks:

Best Overall:
Buy: Xyzal Over The counter Antihistamine Pill
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Best For Non drowsy:
Buy: Claritin Over The counter Antihistamine Pill
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Best For coughing:
Buy: Rite Aid Over The counter Antihistamine Pill
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Best For Seasonal Allergy:
Buy: Valumeds Over The counter Antihistamine Pill
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Best For Allergy sufferer:
Buy: Basic Care Over The counter Antihistamine Pill
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Best For histamine intolerance:
Buy: Zyrtec Over The counter Antihistamine Pill
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Best For daytime:
Buy: Healtha2Z Over The counter Antihistamine Pill
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Best For Spring Allergy:
Buy: Welmate Over The counter Antihistamine Pill
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Best For mucus:
Buy: Good sense Over The counter Antihistamine Pill
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Best For eczema:
Buy: Allegra Over The counter Antihistamine Pill
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Best Overall: Xyzal Over The counter Antihistamine Pill

Xyzal Over The counter Antihistamine Pill
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We are personally inclined towards xyzal over the counter antihistamine pill, it is not so pricy, but it overachieves its purpose and outstanding in important aspects. It is the most effective otc antihistamine out there that relieves symptoms of indoor and outdoor allergies, including sneezing. It is a prescription strength allergy medicine that relieves symptoms of indoor and outdoor allergies, including sneezing. Your itch will be cured if you clean your genital area daily. The Xyzal is taken at night before going to bed so you wake feeling refreshed and symptom-free in the morning when pollen is at its worst. These are small pills and easy to use. They will make you sleepy like Benadryl. It is a long acting antihistamine, meaning it makes it's affect over time.

Why We Like This:
  • Small magical pill, works better and faster than any other brand
  • Tiny pills, easy to swallow, and no flavor
  • Sleepy side effects, works as well as benadryl

Best For Non drowsy: Claritin Over The counter Antihistamine Pill

Claritin Over The counter Antihistamine Pill
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If you are currently in the market looking for a reliable pill for your daily usage, you cannot go wrong with the claritin over the counter antihistamine pill. It takes the edge off seasonal allergies without putting you to sleep. It really does help and this size is much more economical than buying single or a few doses at a time. It's the smallest of all the pills, very tiny, white, round pill and extremely easy to swallow. It has a bottle with a hundred tablets but they only fill up 1/4 space of the bottle. The pills are very tiny too, so if you're sensitive to pill size they should be ideal.

The added benefit this medication has is that it does not cause somnolence.

Why We Like This:
  • A must have for allergy season & runny noses
  • Great allergy tablets and best value
  • Great product for helping with the sniffles

Best For coughing: Rite Aid Over The counter Antihistamine Pill

Rite Aid Over The counter Antihistamine Pill
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Compared with other pill in this category, the rite aid over the counter antihistamine pill has a convenient design. These rite aid diphenhydramine hci 25 mg antihistamine allergy relief tablets are extra small and easy to swallow making them perfect for anyone who has difficulties taking pills. It includes 365 coated minitabs plus it is designed in an easy-to-swallow small tablet. The only mention of the ingredient is Diphenhydramine, there is no other ingredients such as Talc, talcum powder or magnesium silicate which is the pharmaceutical name for talcum powder.

This antihistamine allergy medicine contains 25 mg of diphenhydramine, an antihistamine that is the same active ingredient as the national brand's allergy medication. It can be used in some “pm” or sleep enhancing over-the-counter products. For allergies and sleep, this is a product that you should really always have in your home, in case someone gets a minor allergic reaction, like hives, etc. It is great to help one sleep. If you use the famous Ben brand, for allergy relief, or as a sleep aid, this is just as effective at a much better value.

Why We Like This:
  • Comes in capsules & dropper too
  • Good stuffworks well for eye and nose allergies, makes you a bit sleepy
  • Good investment for long term

Best For Seasonal Allergy: Valumeds Over The counter Antihistamine Pill

Valumeds Over The counter Antihistamine Pill
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The valumeds over the counter antihistamine pill is suitable and reliable and fits well with your daily usage. Living with lifelong chronic illness (Myalgic Encephalomyelitis) it’s beneficial to have a sleep routine. This product functions just like the Brand name and is a great value. It is good for allergies, but it helps with sleep. The allergy medicine for kids and adults also helps reduce sneezing and itchy noses and throats.

Being on a tight disability budget, value is key and this is a good option for either sleep or allergies or both. These dissolve under the tongue relatively quickly. If you use a lot of Benadryl, this is kind of a must.

Why We Like This:
  • Smooth candy coating, easy to swallow
  • Will not throw away but will only take it when out of benadryl
  • Good investment for long term

Best For Allergy sufferer: Basic Care Over The counter Antihistamine Pill

Basic Care Over The counter Antihistamine Pill
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The basic care over the counter antihistamine pill should be able to handle its purpose and duties with ease. These Basic Care All Day Allergy Cetirizine HCl tablets are a generic form of Zyrtec that are very reasonably priced, especially when buying this. Whether you’re indoors or outside, these allergy pills help treat common allergy symptoms such as sneezing, runny nose, itchy nose or throat and itchy, watery eyes. The Tablets are nice and small for human consumption and are affective at combatting allergies.

These are gel cap style pills. They come in a bottle with a child-safe lid. It works for a full 24 hours. It is perfect for year round allergies.

Why We Like This:
  • Works fast and is very effective
  • Relief from severe sneezing and itchiness and wheezing
  • Good value, effectiveness subjective for each situation

Best For histamine intolerance: Zyrtec Over The counter Antihistamine Pill

Zyrtec Over The counter Antihistamine Pill
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The zyrtec over the counter antihistamine pill is suitable and reliable and fits well with your daily usage. The allergy medicine provides powerful, effective relief for a full 24 hours in just a single dose. This is the only brand that helps reduce allergy symptoms without causing drowsiness. It works quickly and works well. It takes care of it right away. It's the next-best thing to allergy shots. It helps with seasonal allergies, dust, pets (to an extent), hives, etc. The pills are white, so no blue artificial or natural color. It is great espresso for the pill count. This product should give you relief for 24 hours.

Why We Like This:
  • Drowsiness, works fast, lasts all day
  • Definitely good for people with stubborn allergies that last more than a few days
  • One of the new comers and featured product

Best For daytime: Healtha2Z Over The counter Antihistamine Pill

Healtha2Z Over The counter Antihistamine Pill
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The healtha2z over the counter antihistamine pill's material feels more premium than its price would suggest. One bottle takes care of the entire household for a month, and it works great. It provides relief from hay fever or other upper respiratory allergies. The pill is easily recognizable and shaped well to be taken with a glass of water. It is non-drowsey. This is another allergy med that lasts 12 hours, maximum. The caplets are easy to swallow as well. This is an automatic refill because it works. It is easy to swallow and effective in the dosage listed on the bottle.

Why We Like This:
  • Acts quickly to combat arthritis pain
  • Larger sized oval pill but pretty easy to swallow
  • Effective med and easy to swallow

Best For Spring Allergy: Welmate Over The counter Antihistamine Pill

Welmate Over The counter Antihistamine Pill
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Compared with other pill in this category, the welmate over the counter antihistamine pill has a convenient design. This beauty reduces drainage, coughing and head miseries. It is not so small that it gets lost in your mouth before you can swallow it. It works better with a decongestant pill also. It reduces coughing as well and also does help with a great deal. These tablets work great and are inexpensive too. It is great to stop sinus drainage during the spring allergy seasons. It works best as a daily preventative taken first thing every morning.

Why We Like This:
  • Priced fairly and easy to swallow
  • Effective otc med, very cost effective
  • Easy to swallow and nice flavor
  • Coated so was easy to swallow even though large

Best For mucus: Good sense Over The counter Antihistamine Pill

Good sense Over The counter Antihistamine Pill
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If you are currently in the market looking for a suitable pill for your daily usage, good sense over the counter antihistamine pill is the natural choice. The active ingredient in goodsense all day allergy is cetirizine hydrochloride, an antihistamine approved for the treatment of both indoor and outdoor allergy symptoms. This is just like Zyrtec and Good Sense does a good job of making medications and supplements that are identical to their big name counterparts. It is used to get itchy forearms and eyes frequently. This is basically a reaction/sensitivity to changes in temperature, smells etc. It's just amazing to have reliable allergy relief for pennies per day.

This medicine is meant to be taken daily, so that an immunity to allergy symptoms is built. It is much more affordable and is every bit as good as the name brand.

Why We Like This:
  • More semi automatic sneezing, itchy nose, and eyes
  • Lot of satisfied buyers

Best For eczema: Allegra Over The counter Antihistamine Pill

Allegra Over The counter Antihistamine Pill
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The allegra over the counter antihistamine pill is specially designed for your regular usage and has all useful features. Allegra hives allergy medicine is made with active ingredient fexofenadine hcl, a non-drowsy antihistamine, so you can take it day or night without drowsiness. It provides powerful relief of persistent itch. It works for itchy skin and is gone pretty quickly. The active ingredient in this, is supposed to be fast acting too. You might want some caffeine with it but it does great, definitely a good one to have on hand for emergencies.

Allegra hives is a non-drowsy allergy medicine, so you don’t have to worry about feeling drowsy after you take it. These tablets are useful to have around, and for 30 tabs, a good value.

Why We Like This:
  • A great non-drowsy antihistamine to have on hand for hives and bee stings
  • You do not get drowsy and you only take it once a day
  • Good brand reputation