The 11 Best Prescription Allergy medicines (2023 reviews)

There are several advantages of having a prescription allergy medicine. Let’s take you step by step, type by type, and find the best prescription allergy medicine for you.

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Our Top Picks:

Best Overall: Buy: Claritin Prescription Allergy Medicine READ REVIEW

Best For Seasonal Allergy: Buy: Basic Care Prescription Allergy Medicine READ REVIEW

Best For coughing: Buy: Basic Care Allergy Medicine READ REVIEW

Best With Nasal decongestant: Buy: Xyzal Prescription Allergy Medicine READ REVIEW

Best For Spring Allergy: Buy: Flonase Prescription Allergy Medicine READ REVIEW

Best For bad Allergy: Buy: Healthcareaisle Prescription Allergy Medicine READ REVIEW

Best For Nasal Congestion: Buy: Healthcareaisle One Tablet READ REVIEW

Best For severe Allergies: Buy: Allegra Prescription Allergy Medicine READ REVIEW

Best For run: Buy: Xyzal Hour Relief READ REVIEW

Best For immediate Relief: Buy: Genexa Prescription Allergy Medicine READ REVIEW

Best For severe Allergy: Buy: Safrel Prescription Allergy Medicine READ REVIEW

Best Overall: Claritin Prescription Allergy Medicine

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Compared with other medicine in this category, the claritin prescription allergy medicine has a design with broader appeal. It takes the edge off seasonal allergies without putting you to sleep. It's bad enough to have alligators in your pool, rattlesnakes and coral snakes in your yard, and fire ants and scorpions just about everywhere. It works for the sneezing runny nose and eye watering with claritin. It is an antihistamine so it hinders the cascade triggered by indoor & outdoor allergens.

The added benefit this medication has is that it does not cause somnolence. It really does help and this size is much more economical than buying single or a few doses at a time. The package may also be presented as half of the size of this package, containing one bottle.

• Great allergy tablets and best value
• A must have for allergy season & runny noses
• Delivers what they promise

Best For Seasonal Allergy: Basic Care Prescription Allergy Medicine

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Not everyone likes to purchase medicine for their regular usage, but the basic care prescription allergy medicine would be an anomoly. Whether you’re indoors or outside, these allergy pills help treat common allergy symptoms such as sneezing, runny nose, itchy nose or throat and itchy, watery eyes. This is a year’s supply of non-drowsy antihistamine. It's a generic alternative to Zyrtec liquid gels. It comes with 30 tabs additionally it is best for short term use. These allergy pills are definitely a great value.

• Good value, effectiveness subjective for each situation
• Non-drowsy, easy to swallow and works quickly & effectively
• Good brand reputation

Best For coughing: Basic Care Allergy Medicine

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Not everyone likes to purchase medicine for their daily purpose, but the basic care allergy medicine would be an anomoly. This is a perfect alternative that works exactly the same and saves you a lot of money. It provides indoor and outdoor allergy relief of symptoms such as sneezing, runny nose, itchy throat or nose and itchy, watery eyes for up to 24 hours. The smell is definitely a strong bubblegum. This is a good option if you've been told to give cetirizine to a young child. The bottle is big enough to last a month for both children. It is great for spring time allergy season.

• Lasts longer than other allergy meds
• Great allergy meds for seasonal allergies
• Great flavor and works all day
• Works great for insect and spider bites

Best With Nasal decongestant: Xyzal Prescription Allergy Medicine

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We would, of course, be remiss if we didn't mention xyzal prescription allergy medicine for regular usage. It's the only allergy medicine strong enough. It is easy to swallow pills, they really work. It provides 24 hour symptom relief after just one day. They redid the formula so it blocks more histamine and causes less drowsiness. It works as well as any other allergy medication. It mercifully relieves symptoms for the night and awakens feeling normal. It is effective for 24 hours and that it is recommended to be taken at night.

• Offers a full 24 hours of relief
• Wet eyes, no drippy nose, no itchiness or sneezing, it's amazing
• Doesn't make you feel drowsy or hype you up
• Easy to take, don't leave a taste in your mouth

Best For Spring Allergy: Flonase Prescription Allergy Medicine

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If you often find yourself scrambling for appropriate and satisfactory medicine, flonase prescription allergy medicine should be your first option for buying. Allergy nasal spray that provides 24 hour all-in-one relief for even your worst seasonal, year-round, indoor and outdoor allergy symptoms. It is used for years and it helps tremendously during allergy season. It calms any irritation in the nose due to pollen/allergies and a runny nose. It is perfect for people who work in dusty areas. It comes with up to 72 doses/sprays, if you spray this once a day in each nostril this should last about 1 month.

If you are good about using it properly it is an effective product & costs much less than a prescription. It is very effective for runny nose.

• Great product for allergies and sinus problems
• Effectively, odorless and easy to use
• Easy grip, longer length is more comfortable to use
• An effective nasal spray allergy relief solution that works for adults

Best For bad Allergy: Healthcareaisle Prescription Allergy Medicine

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The healthcareaisle prescription allergy medicine is suitable and reliable and fits well with your regular usage. Anyone who needs zyzal as allergy relief in life, this is a superb alternative. It is an allergy medicine clinically proven to relieve indoor and outdoor allergies. It provides 24 hours of relief from indoor and outdoor allergies. This is the over the counter strength, for anything stronger you need a prescription.

Each original prescription strength antihistamine tablet starts working in 60 minutes and provides 24 hours of relief from indoor and outdoor allergies. It is good for allergy relief but has side effects. It is great for the quantity compared to xyzal.

• More scratching and sneezing and rolling around on the floor
• Lasts 24 hrs of great relief
• Lot of satisfied buyers

Best For Nasal Congestion: Healthcareaisle One Tablet

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The healthcareaisle one tablet should be able to handle its purpose and duties with ease. Cetirizine tablets provide 24 hours of allergy relief. It is good value for 300 tablets with recommended dosage of one tablet per day. Each original prescription strength antihistamine tablet provides 24 hours of relief from indoor and outdoor allergies. The Cetirizine Hydrochloride provides 24 hours of allergy relief.

• Save money and no sneezing too
• Helped during the academy season with the nasal congestion and coughing
• Excellent generic alternative to expressive zyrtec

Best For severe Allergies: Allegra Prescription Allergy Medicine

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Best part: allegra prescription allergy medicine costs comparatively low and it is available to ship in 24 hours. If you are a light allergy sufferer these might be good for you. It provides fast, strong, non-drowsy, noticeable relief of indoor and outdoor allergy symptoms. It is indicated for the temporary relief of symptoms due to upper respiratory allergies or hay fever, which can be caused by an allergic response to indoor or outdoor allergens.

These are smaller in size than the 24 hr tabs. It is better priced and non-drowsy. It's great for most people.

• Works really well to prevent and keep hives at bay
• Non drowsy and works within a half to an hour
• Lot of satisfied buyers

Best For run: Xyzal Hour Relief

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The xyzal hour relief should be able to handle its purpose and duties with ease. It is a prescription strength allergy medicine that relieves symptoms of indoor and outdoor allergies, including sneezing and pollen. If you have to drive on the following day, or do anything critical and demanding, this one WILL make you sleepy and not fit to drive. It is great for seasonal allergies.

Xyzal is taken at night before going to bed so you wake feeling refreshed and symptom-free in the morning when pollen is at its worst. It is the only antihistamine that works to stop the itchy hives. It provides 24 hour symptom relief after just one day. It is small and easy to swallow.

• Excellent for allergic reactions that keep coming back
• Full 8 hours sleep plus an additional 19 minutes
• The best 24 hour allergy medication over the counter

Best For immediate Relief: Genexa Prescription Allergy Medicine

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The genexa prescription allergy medicine's superior materials makes sure that it ages well with use. It is formulated to promote allergy relief in symptoms such as irritated eyes, runny nose, sinus pressure, sneezing, nasal congestion, and itchy nose and throat. It is good as any other allergy med but without all the side effects. Once it begins to take effect, it's excellent but it lasts no more than six hours. It is easy to use and works great and very good value for the money.

This product does its job taking the edge off enough to function well. It is a real remedy, made clean. The chewable tablets seem to take effect quickly and work well at combatting seasonal allergy symptoms.

• Works fast and it works great
• Non gmo, homeopathic and easy to take
• Even around hay for the horses, a lot of brush, and dirt roads, etc

Best For severe Allergy: Safrel Prescription Allergy Medicine

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The safrel prescription allergy medicine's high-end materials makes sure that it ages well with use. This is a Claritan equivalent with Loratadine antihistamine. This powerful antihistamine contains 10 mg of loratadine, usp in each anti-allergy tablet and effectively treats indoor allergies caused by dust, mold, and pet dander, as well as outdoor allergies caused by tree pollen, weeds, and grasses. The active ingredient in this product is loratidine, an antihistamine approved for the treatment of both indoor and outdoor allergy symptoms. It is easy to throw into a purse or pocket on the way out the door.

This pack has tons of pills. The non-drowsy portion is very effective. These tiny tablets may be taken conveniently for improved relief, and the small container can be carried in your pocket. The bottle/container is small and compact so it’s easy to throw into a purse or pocket on the way out the door.

• Calms allergy symptoms with no drowsiness
• Will last a while and has a great expiration date too
• Good brand reputation