We consider a handshake mouse to be a worthy investment in the long run. We are here to help you choose the best one for your needs from all the best available products in market today.

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Our Top Picks:

Best Overall: Buy: Logitech Handshake Mouse READ REVIEW

Best For High Performance: Buy: Amazon Renewed Handshake Mouse READ REVIEW

Best For Thumb Pain: Buy: Memzuoix Handshake Mouse READ REVIEW

Best For Travel: Buy: Hotweems Handshake Mouse READ REVIEW

Best For Customer Support: Buy: Evoluent Handshake Mouse READ REVIEW

Best For Personal Preference: Buy: Nulaxy Handshake Mouse READ REVIEW

Best For Right Clicking: Buy: Lekvey Handshake Mouse READ REVIEW

Best For Fast Easy Bluetooth: Buy: Mojohome Handshake Mouse READ REVIEW

Best For Medium Size: Buy: Jtech Digital Handshake Mouse READ REVIEW

Best For Nice Long Cord: Buy: Kensington Handshake Mouse READ REVIEW

Best With No Problem: Buy: More&Better Handshake Mouse READ REVIEW

Best For Wireless Connection: Buy: Delux Handshake Mouse READ REVIEW

Best Overall: Logitech Handshake Mouse

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Logitech has been making good-quality mouses for years, thanks to a combination of clever design and high-end materials. The Logitech Handshake Mouse allows for smooth glide, It works well for thumb pain and has an intuitive design. Make sure this fits by entering your model number. And, the mouse is a great size, It is great for gamers and has a high-end design.

The mouse is best for long battery, It is great for an ergonomic keyboard and has a silent design. In addition, it feels great, makes for nice smooth, it is built for high-precision and has an awesome design. Most importantly, the logitech handshake mouse works flawlessly, is made with an ergonomic shape, it is incredible and has a good design.

Most customers quickly discovered that the mouse is a no-frills mouse without 1000 buttons to program, but it works great and feels comfortable. And, they strongly agree that the mouse is used to, amazing comfort. Further, a few strongly agree that the angle makes it a much more comfortable mouse to use for long periods of time.

• This will switch between them fairly seamlessly, taking only a second to switch modes.
• This is the best vertical mouse currently available.
• This comes with both a logitech unifying receiver and bluetooth.
• This mouse is completely specific to the right hand.

Best For High Performance: Amazon Renewed Handshake Mouse

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The Amazon Renewed Handshake Mouse is suitable and reliable and fits well with your regular use. The amazon renewed handshake mouse is outstanding, It is easy to adapt and has a very comfortable design. Delivers the optimal ergonomic posture and performance. This certified refurbished product is tested and certified to look and work like new.

The mouse is very quiet, it comes with good customer service and has an awesome design. And, it is good enough and has a comfortable design. Most importantly, the amazon renewed handshake mouse is used for useful features and has a good design.

Most buyers found that the mouse includes hyperscrolling... as it should have from the start. Further, they say that the mouse has always been exactly as described with no problems. And, a few strongly agree that the mouse is a trade-off between an aching hand and an aching wrist, arm, and shoulder. Overall, for most buyers, it was what they were looking for.

• This is a great alternative to a traditional mouse for wrist pain when used correctly.
• This is better than a vertical mouse, but presents it’ssssss own issues.
• This is a great mouse for those with long fingernails.
• This works well with macbook and is also good for someone with big hands.

Best For Thumb Pain: Memzuoix Handshake Mouse

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The Memzuoix Handshake Mouse's superior materials makes sure that it ages well with use. The memzuoix handshake mouse is great for thumb pain, It comes easy-to-use and has a simple design. This ergonomic mouse is friendly for large hands, If you have small hands and you have never used any kind of mouse, it will take several days to get used to. The wireless mouse has an '' on / off '' switch will save battery life even more.

The mouse is designed for home office, It comes with a power switch and has a special design. Lastly, the memzuoix handshake mouse is serviceable, works as intended, It is great for solid build and has a very comfortable design.

Most customers opine that the mouse is used to how the cursor moves. Also, a few say that the mouse has never broken or even the battery cover come open. And, they strongly agree that the mouse is a nice combo of the other two. Overall, most buyers agree that the mouse suits them best, and no one questions it.

• This works well to relieve that pain.
• The mouse clicks are in the right position and everything feels comfortable.
• This has a design for thumb rest and grip well.
• This measures 16.5 cm from the tip of the finger to the wrist.

Best For Travel: Hotweems Handshake Mouse

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If you often find yourself confused about a convenient and suitable mouse, Hotweems Handshake Mouse should be your first option for buying. Also, the hotweems handshake mouse is very cool, It is best for a good deal and has an excellent design. It enters sleep mode after you leave for 8 minutes. And, the mouse is perfect for coffee shop, looks nice, it makes for easy setup and has a durable design. Finally, the hotweems handshake mouse is available in 5 vibrant colors: stormy black, snow white, graphite grey etc.,.

Almost all customers opine that the mouse is fine for a year and then it stopped working correctly. Further, they also found that the mouse has all the basic 5 buttons, it has a changeable dpi sensitivity of 800/1200/1600/2000/2400,, it's lightweight, and it's inexpensive. And, a few say that the mouse sleeps on its own after 8 minutes of inactivity. Overall, the tone of buyers is very positive and we believe that the mouse suits the purpose.

• Slip in your pocket or toss in your bag.
• It is easy to plug in and get going.
• It is easy to navigate programs with.
• This is suitable for men or women with average hands.

Best For Customer Support: Evoluent Handshake Mouse

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Compared with other mouses in this category, the Evoluent Handshake Mouse has a convenient design. The evoluent handshake mouse looks brand new, it looks pretty and has a super comfortable design. Install the evoluent mouse manager onto your computer to configure the verticalmouse's buttons. The verticalmouse 4 ( right handed mouse ) by evoluent helps avoid forearm twisting for comfort and good health.

Lastly, the evoluent handshake mouse is compatible with Windows xp, 7, 8 and 10, Mac and Linux systems.

Most buyers agree that the mouse is good for pain, but the left click button has issues. Further, a few strongly agree that the mouse is used to ache when using a regular mouse. Moreover, a few strongly agree that the mouse is used to having to take ibuprofen every day to feel comfortable enough to sit down and use the computer. Without any doubt, this mouse passed the test and had very satisfied buyers eager to share their experience.

• This mouse has made all the difference in the world.
• This is designed for hand position, especially to transition from the regular mouse.
• This mouse is an absolute dream, when combined with a comfy mouse pad.
• This is thoughtfully sculpted for uncompromised comfort and easy-to-reach programmable buttons.

Best For Personal Preference: Nulaxy Handshake Mouse

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We know from years of feedback from readers, amazon sellers, and family and friends what most people want in a convenient and appropriate mouse. The Nulaxy Handshake Mouse is exactly that - it's a simple mouse that hits all the right notes. The nulaxy handshake mouse comes with 800 / 1200 / 1600 dpi resolution optical tracking technology, provides much more sensitive than standard optical mice with smooth and precise tracking on different kinds of surfaces. Make sure this fits by entering your model number. The setup of the wireless vertical mouse is pretty easy, no driver installation needed.

The mouse is good for office use, Its buttons are solid and it has a convenient design. Further, this is brand new, fits for the desktop, It fits well for cheap feeling and has a cool design. Finally, the nulaxy handshake mouse gets the job done, is used for perfect size, it is ready to go and has a comfortable design.

Most customers found that the mouse has a power saving mode. Also, a few also found that the mouse does its' job very well, and for the last week or so, has been working without issue. And, a few strongly agree that the mouse is really a matter of personal preference. In conclusion, at the price, they believe that they got a steal of a deal with it.

• Added forward/backward buttons provide convenience when webpage browsing, increasing your work efficiency.
• This works well and at a great price.
• This is compatible with windows 2000 / xp / vista /7/8/10/ mac / linux.
• This is really acting up changing the batteries.

Best For Right Clicking: Lekvey Handshake Mouse

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The Lekvey handshakemouse is capable of outshining several other mouse featured in this list in overall features for the price point. The Lekvey handshake mouse is not compatible with Mac or Apple products. Manufacturer says: Rest assured that all acedada our lekvey ergonomic vertical mouse have unconditional 24. This mouse provides a low - cost, effective solution for multiple computing needs.

The mouse is made for increased functionality and comfort, This rechargeable vertical mouse combines a handshake grip. Also, the mouse falls asleep, It is built with good ideas and has a great design. Lastly, the Lekvey Handshake Mouse is made with a soft feel, It is great for accurate positioning and has a light design.

Most buyers agree that the mouse has an internal battery, rechargeable by a standard micro-usb cable. And, a few also found that the mouse is perfectly placed for left and right clicking. Moreover, a few also found that the mouse is used to, and the battery hasn't died yet. Obviously, this mouse passed the test and had very satisfied buyers eager to share their experience.

• This is perfect to prevent hand issues.
• The former method will make the mouse click wherever it last froze.
• This looks cool and it's supposed to be easier on the wrists.
• This is used to because of the way it sits.

Best For Fast Easy Bluetooth: Mojohome Handshake Mouse

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Not everyone likes to purchase a mouse for their daily use, but the Mojohome Handshake Mouse would be an anomoly. The mojohome handshake mouse is good enough, Most importantly, it is good for web browsing and has a comfortable design. The Manufacturer says: Our mouse maintains a neutral "handshake" grip, keeping your arm in a comfortable position that will prevent stress and discomfort in your hands, wrists, and forearms associated with carpal tunnel and other repetitive stress injuries. Also, it is comfortable to move, it has silent click and has an excellent design.

The mouse comes with an advanced, optical tracking sensor, Our mouse is highly responsive and precise. Finally, the mojohome handshake mouse has dropped connections, it works great and has an intuitive design.

Almost all buyers opine that the mouse is suitable for right hand use. Moreover, they strongly agree that the mouse comes in handy, along with the next page and back page buttons. Further, they also found that the mouse is great for the following reasons. To sum up, at the price, they believe that they got a steal of a deal with it.

• The BT connected without issue, and the mouse feels nice.
• This is completely silent, it allows for very high quality and has a comfortable design.
• This one is even more comfortable.
• These features, especially the dual bluetooth/wifi option.

Best For Medium Size: Jtech Digital Handshake Mouse

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The Jtech Digital Handshake Mouse's high-end materials make sure that it ages well with use. The jtech digital handshake mouse is good enough, is beautiful, it goes strong and has an innovative design. Manufacturer says: We know that once you’ve become familiar with its comfortable, easy to use design, you’ll be asking yourself why you didn’t go ergonomic a long time ago. This ergonomic mouse features a detachable non - skid anti - sweat palm rest that reduces drag, making it easier to maneuver the mouse across the surface of a mousepad, tabletop, desktop, etc.

The mouse allows for smooth glide, it is perfect for the auto - off feature and has a super comfortable design. In addition, this reduces arm/wrist/hand strain additionally allows for full freedom of ergonomic mouse movement. Finally, the jtech digital handshake mouse is pretty cool, It looks cool and has a very nice design.

Almost all buyers found that the mouse is good for people with arthritis. Also, they strongly agree that the mouse is a great mouse for those needing an offset feel. Also, a few also found that the mouse is really comfortable and ergonomic. Overall, buyers found this to be one of the best mouses for daily purposes.

• This takes a lot of getting the hang of it.
• The rainbow lights run non - stop while the mouse is awake.
• This is much more livable when it comes to price.
• This reduces wrist discomfort significantly.

Best For Nice Long Cord: Kensington Handshake Mouse

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We would, of course, be remiss if we didn't mention Kensington handshakemouse for daily use. The Kensington handshake mouse is really good, it has the best price and has a beautiful design. And tested wireless connectivity via 2.4ghz with a range of 33 feet/10 meters. The mouse goes into a deeper sleep, and clicking a button or using the scroll wheel wakes it up.

The mouse is made for good value for money, fits right for the right size, It is great with prompt service and has a superior design. Finally, the Kensington handshake mouse has bought this one, It makes no difference and has a special design.

Most buyers found that the mouse fit the bill well. and works well well well. Moreover, a few also found that the mouse has plenty of buttons for right or left. Further, a few say that the best replacement for the previous mouse, the wheel is n't working. Obviously, this product passed the test and had very satisfied buyers eager to share their experience.

• It is good to have a supply of these on hand.
• This is lazer operated and very smooth and comfortable to work with.
• This is so cheap, but definitely turned out to be a great buy.
• This has no built-in keypad like some mice.

Best With No Problem: More&Better Handshake Mouse

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Compared with other mouses in this category, the better handshake mouse has a convenient design. The better handshake mouse feels smooth and has a super comfortable design. The ergonomically-designed thumb rests and grips fit the contour of your palm for maximum comfort. Note: If the vertical mouse can not work smoothly, please check if the battery is out of power, because low batteries will affect the performance.

The mouse is easy to install, is made for desktop computers. It tracks very well and has a scientific ergonomic design. Finally, the More&Better Handshake Mouse can check for compatible systems, It is stylish and has great style.

Almost all buyers found that the mouse is easy to grip, and the controls work perfectly. In addition, a few say that the mouse is cordless and rechargeable via USB, making it perfect. Also, they say that the mouse is because the thumb goes in the concave side of the mouse as shown in the picture inset. To sum up, most buyers found the mouse is functionally comfortable and no one questions it.

• This is used to, but it's very comfortable now.
• This mouse is definitely set up as a righty.
• This is designed for people with hand wrist/limitations.
• Six buttons give you improved control over your computer's systems.

Best For Wireless Connection: Delux Handshake Mouse

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The Delux Handshake Mouse's high-end materials make sure that it ages well with use. Further, the delux handshake mouse is extremely smooth, it works perfectly and has a comfortable design. It is important to equip myself with the correct size vertical mouse, which lets you easily get used to the use of a vertical mouse, and more helps dramatically comfort your hands. Further, the mouse is good for relief from the wrist, is very inexpensive, it is super easy and has a stable design. Lastly, the delux handshake mouse is available in 2 different colors: white and black.

Almost all buyers opine that the mouse is good for casual gaming but not at fps for sure. In addition, they strongly agree that the mouse is a bit lighter and the logitech version has a nicer rubber coating compared to the more slippery plastic of the delux. Also, they also found that the delux mouse is smooth plastic all over, meaning it does not have that ‘ rubber ’ texture ( which is featured on the logi ) which will inevitably become sticky over time.

• They can not choose the color of the lights.
• Just find your correct one according to your palm size.
• The mouse has been helpful in relieving wrist and finger strain.
• This does take some getting used to.