The 10 Best Puppy Pee Enzyme cleaners (2023 reviews)

We consider a puppy pee enzyme cleaner to be a worthy investment in the long run. We are here to help you choose the right one for your needs from all the best available products in market today.

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Our Top Picks:

Best Overall: Buy: Natures Miracle Puppy Pee Enzyme Cleaner READ REVIEW

Best For car: Buy: Natures Miracle Odor Remover READ REVIEW

Best For human: Buy: Rocco Roxie supply co Puppy Pee Enzyme Cleaner READ REVIEW

Best For Pee Smell: Buy: Simple Solution Odor Remover READ REVIEW

Best For grass: Buy: Bubbas Rowdy friends Puppy Pee Enzyme Cleaner READ REVIEW

Best For turf: Buy: Naturvet Puppy Pee Enzyme Cleaner READ REVIEW

Best For tile floor: Buy: Out Puppy Pee Enzyme Cleaner READ REVIEW

Best For Pet Accidents: Buy: Simple Solution Puppy Pee Enzyme Cleaner READ REVIEW

Best For Fresh messes: Buy: Petsafe Puppy Pee Enzyme Cleaner READ REVIEW

Best For non heavily soiled areas: Buy: sprinkle sweep Puppy Pee Enzyme Cleaner READ REVIEW

Best Overall: Natures Miracle Puppy Pee Enzyme Cleaner

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Natures miracle puppy pee enzyme cleaner is the epitome of what a great cleaner should be. The best formula to use for urine-specific messes is the Urine Destroyer. It gets rid of odor and cleans dirt and stains. It actually cleans up the mess and leaves the floor smelling nice and stain free. This product works very well to remove pet stains. It has a strong, lingering smell. It is perfect for puppy house training. This formula really attacks the hell out of odor AND stains just as equally.

• Great for dog and kid accidents
• Excellent, great for anyone who has a pet or pet service business
• Best pet cleaning spray for stains and odors
• Works well and helps prevent the dogs from returning to the same spot

Best For car: Natures Miracle Odor Remover

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Natures Miracle makes beautiful and great cleaner with classic and smartly choosen materials. Nature’s Miracle advanced stain & odor eliminator for dogs is an enzymatic, severe-mess stain and odor remover that actually discourages re-soiling by removing the odor of even the toughest dog messes. It offers the same level of excellent odor removal and pretty decent stain removal as other versions of nature's miracle.

This product does a good job on odor. It works on sealed or finished concrete floors. The Sunny Lemon has a very strong smell. It is great for getting rid of gross dog urine odor and stains. The Dog odor control formula gets your home smelling clean again. This has a lemon scent which, while not bad, is not as pleasant as the original or lavender.

• Leaves fresh scent but not too heavily scented
• Works great on stains from puppy accidents
• A must-have for pet owners, especially older pets that are prone to accidents

Best For human: Rocco Roxie supply co Puppy Pee Enzyme Cleaner

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Rocco Roxie Supply Co offers a variety of cleaner for personal choice and yet maintaining quality in all the variants. This is the ONLY enzyme cleaner that actually removes cat urine smell for humans and other cats. It has an interesting scent but far better than the pet odors it cleans up. It is a bit heavy of a scent. It's so nice to not only know that you are actually CLEANING thoroughly and leaving your home with a very nice fresh clean smell to boot.

This works great to clean up puppy training mishaps. The smell of the product isn't full of perfume, it is fresh and clean. It is great to clean up after any organic mess.

• Worked great to remove puppy pee accidents
• Great for artificial turf and dogs
• Gets rid of poo / pee smell instantly for wood floors
• Very effective in eliminating the cat urine odor

Best For Pee Smell: Simple Solution Odor Remover

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We know from years of feedback from readers, customers and amazon sellers, what most people want in a convenient and appropriate cleaner. The simple solution odor remover is exactly that - it's a simple cleaner that hits all the right notes. This powerful pet stain and odor remover is formulated to help break down, neutralize, and permanently remove extreme stains such as dog and cat urine, feces, or vomit. It smells like a clean rug, sort of floral/clean linen if they have a baby. It does a really good job cleaning up dog pee and masking the smell.

The Extreme stain and odor remover is a professional strength pro-bacteria and enzyme formula that breaks down and eliminates both new and old stains and odors. It is easy to remove and replace with strong velcro closures. This has a pleasant scent going on, which disipates in a reasonable amount of time. The elimination of odors is immediate and there is no sickeningly-sweet smell.

• Works very well on dog urine and feces
• Good for submissive and excitement urination
• Works great and rids smell, great stuff
• A real miracle, highly recommended for cat urine

Best For grass: Bubbas Rowdy friends Puppy Pee Enzyme Cleaner

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If you often find yourself scrambling for appropriate and satisfactory cleaner, bubbas rowdy friends puppy pee enzyme cleaner should be your first option for buying. If you want a cleaner that will remove smell well enough for human noses, this stuff is the bomb. It has a distinct smell but not horrible. It really clears up the smell and it's. It is easy to use, best thing for pet stains. It does smell a bit strong with a chemical smell at first but it will eventually go away.

It comes with 8 cats, 2 large dogs and a puppy, so you can say this product works. There is no stain or residue left on the carpet. It is a good pet odor solution.

• Stains, no urine or fecal odors, no discoloration
• , smells good and eliminates the scent mark of the piss spot
• Delivers what they promise

Best For turf: Naturvet Puppy Pee Enzyme Cleaner

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The naturvet puppy pee enzyme cleaner is capable of outshining several other cleaner featured in this list in overall features in its price range. This spray is amazing and works the first time around. It works for urine smell well. The citronella has a nice smell to it, and it really does help with the flying pests. It is great in dog areas and safe on artificial grass. It has a light and refreshing scent that you start smelling almost immediately. It does have a pleasant smell, but that wears off quickly. The citronella is fairly strong smelling. This item does work well to eliminate the pet urine smell.

• Easy to use, just hook up to water hose
• Works great on a gravel dog run
• Great for having back yard parties
• Really takes care of odor and mess

Best For tile floor: Out Puppy Pee Enzyme Cleaner

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Out offers a variety of cleaner for personal choice and yet maintaining quality in all the variants. The Petcare orange oxy stain & odor remover is safe to use around children and pets when used as directed. It cleans and removes the urine smell completely. This stuff works great on both getting the stain up & neutralizing the odor without an overpowering perfume smell. It does lighten old spots considerably. It is great for pet spot remover for messes. It is sprayed on the dog urine, and it no longer shows under the black light. The scent somehow totally neutralizes any smell.

• Great for cleaning up after pets
• Works great to remove puppy stains
• Helps with the smell & stains
• Cleans stains pretty well, absorbs odors

Best For Pet Accidents: Simple Solution Puppy Pee Enzyme Cleaner

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The simple solution puppy pee enzyme cleaner might be a relatively new release, but it's still nothing short of impressive this year, thanks to multiple price cuts and added new features over the past few months. This floor cleaner is great for urine or poop accidents on hard floors. It cleans old pet markings and it is great to remove odors. It is WONDERFUL as it works on nullifying the enzymes. This product cleans nicely and leaves a smooth finish. It is great for removing odor but not spots. This cleans well and neutralizes the smell. It is a must for pet lovers.

• Very low odor, non-toxic, and gets up the nasty stuff within seconds
• Removes odor and stain from hardwoods, works well
• Works really well on older pet odors

Best For Fresh messes: Petsafe Puppy Pee Enzyme Cleaner

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Not everyone likes to purchase cleaner for their daily purpose, but the petsafe puppy pee enzyme cleaner would be an anomoly. This is an enzyme based cleaner that uses non. It is good for fresh messes, ok for stubborn long term stains. It's very mild in terms of scent, which is a plus since these types of cleaners sometimes go overboard on the scent level.

This cleaner only contains naturally occurring organic compounds. It is also effective for cleaning indoor or outdoor pet toilet areas and outdoor synthetic grass. The pad stays smelling clean. There is no stain left nor any odor. This is a decent enzyme-based cleaner to get rid of urine odor.

• Petsafe enzymatic cleaners and odor removers
• Great spray bottle, firm believer in the enzyme's abilities
• Great scent, works really well at breaking-down poop for easy cleaning
• Keeps odors away until the next cleaning

Best For non heavily soiled areas: sprinkle sweep Puppy Pee Enzyme Cleaner

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The sprinkle sweep puppy pee enzyme cleaner should be able to handle its purpose and duties with ease. This Sprinkle & Sweep Pet Stain and Odor Remover does fine for stains, but the smell of cat urine is still there. It works well at neutralizing pet odors, even glandy butts. It is formulated with non-toxic ingredients that are safe for children and pets.

This cleaner deodorizes well in the trash, with no chemical smell. It comes with complete removal, so your pet won’t be tempted to use the same spot as their litter box or bathroom over and over. This spray is easy to use and works. It works well for light cleaning duties and works well to eliminate smells.

• Great for delicate areas and around kiddos
• Sprinkle & sweep enzyme & bacteria based stain & odor eliminator
• A must have for pet owners
• Great for light cleaning and eliminating odors